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Principal Scientist Bioanalysis and Metabolism - DMPK - All Gender

date publiée 10/07/2022
type de contrat Full time
reférence de l’emploi R2652751
location Chilly-Mazarin, France

Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.

OUR TEAM

Within Sanofi's R&D, Drug Metabolism & Pharmacokinetics (DMPK) works in close collaboration with the other entities in Sanofi’s Global Research Platform and the Hubs, in order to support Therapeutic Area clusters to optimize, select and evaluate development candidates for optimal properties of target engagement and minimal risks related to bioavailability, duration of exposure or covariates driving variability. 

Main outcomes include selection of most promising scaffolds; optimization of chemical series and other modalities; demonstration of target engagement and establishment of PK/PD relationships; and continuous evaluation and refinement of translational parameters affecting probability of success in clinical studies. At Sanofi multiple modalities are at the Therapeutic Areas disposal including synthetic molecules, monoclonal antibodies, bi & tri specific antibodies, fusion proteins, nanobodies and gene therapies (not inclusive).

Today DMPK France reinforces its laboratory activities on the support of biotherapeutics, including several modalities such as mAb/Nb hybrids, fusion proteins, ADCs, NDCs.

In this context, the DMPK/Metabolism Group is seeking for an expert in structural analysis with a strong expertise in biotransformation and enzymology applied to biotherapeutics plus a good knowledge in the drug metabolism of small molecules.

KEY RESPONSIBILITIES

  • Characterize metabolites of both large and small molecules, based on an excellent understanding in drug metabolism, structural analysis, enzymology, and biochemistry
  • Master state-of-the-art high resolution mass spectrometers
  • Develop analytical approaches for the assessment of large molecule’s biotransformation using HPLC/MS methods associated to adequate sample preparations including protein precipitation, immuno-capture, reduction, enzymatic digestions
  • Monitor metabolism studies applied to large and/or small molecules using both cold and radiolabeledmaterials
  • Communicate results across the Research Organization and at global level
  • Ensure presentations at international conferences
  • Write publications

PROFILE 

Experience & Education

  • PharmD, PhD in Mass Spectrometry or in Analytical Sciences related to proteomics and protein characterization with 3-5 years' experience in the pharmaceutical field
  • PhD level in Analytical Sciences and Mass Spectrometry

Soft skills

  • Demanding & problem solving oriented
  • Pedagogy & assertiveness
  • Analytical rigor & ability to communicate and write in English: reports, posters, publications in scientific papers

Technical skills

  • Expertise & experience in protein sample preparation, extraction, reduction, and digestion
  • Expertise & experience in high resolution mass spectrometry and mass spectra deconvolution
  • Understanding in drug metabolism of small molecules
  • Understanding in enzymology, and biochemistry

Behaviors

  • Confident, motivated and pro-active person

Languages

  • English read/spoken/written

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

As part of its diversity commitment, Sanofi is welcoming and integrating people with disabilities.

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